OBS Entropy Labs
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Overview
OBS MIRD Entropy Labs, the advanced research arm of the OBS Group, is at the forefront of innovation in interdisciplinary scientific exploration. With a commitment to addressing the world’s most complex challenges, the lab leverages state-of-the-art technologies, including Exa-scale quantum supercomputing, to push the boundaries of knowledge. As a Synthetic Pathways Research Scientist, you will play a pivotal role in exploring and designing novel synthetic routes, focusing on chemical, biochemical, and material synthesis with applications across multiple industries, including pharmaceuticals, energy, and advanced materials.
This position offers the opportunity to work on groundbreaking research in synthetic chemistry and related disciplines, developing sustainable, efficient, and innovative pathways for the synthesis of complex molecules and materials. You will collaborate with an interdisciplinary team of chemists, physicists, computational scientists, and engineers to create solutions that impact real-world applications.
Key Responsibilities
Research and Development
Design and develop innovative synthetic pathways for complex molecules, materials, or biochemical systems.
Explore sustainable and green chemistry approaches to minimize waste and improve efficiency in synthetic processes.
Utilize advanced computational methods to model and predict reaction mechanisms, thermodynamics, and kinetics of synthetic pathways.
Experimental Validation and Scale-Up
Conduct laboratory experiments to validate theoretical models and optimize synthetic protocols.
Develop scalable synthesis methods for industrial applications, ensuring reproducibility and efficiency.
Work on integrating automation and robotics into experimental workflows to enhance throughput and precision.
Interdisciplinary Collaboration
Collaborate with computational chemists and physicists to simulate and analyze synthetic processes using quantum and classical computational tools.
Engage with engineers to design and implement innovative reactor systems and process optimization strategies.
Partner with experts in materials science to synthesize novel compounds for advanced applications in energy storage, catalysis, and nanotechnology.
Knowledge Dissemination and Reporting
Publish findings in peer-reviewed journals and present at international conferences.
Prepare detailed technical reports and documentation for internal and external stakeholders.
Contribute to workshops, seminars, and training sessions to foster knowledge sharing within the lab and the broader scientific community.
Focus Areas of Research
Chemical Synthesis: Development of novel catalysts, reagents, and reaction conditions to enable innovative synthetic transformations.
Biochemical Pathways: Engineering metabolic pathways for the synthesis of pharmaceuticals, biofuels, and biomaterials.
Materials Synthesis: Design and fabrication of advanced materials, including polymers, nanomaterials, and composite systems.
Sustainable Chemistry: Integration of eco-friendly methodologies, renewable resources, and energy-efficient processes.
Computational Chemistry: Application of quantum mechanics and molecular simulations to predict and optimize synthetic routes.
Ideal Candidate Profile
Educational Background: Academic Profile in Organic Chemistry, Inorganic Chemistry, Biochemistry, Materials Science, or a related field with a strong focus on synthetic chemistry.
Technical Expertise:
Proficiency in modern synthetic methodologies, including catalysis, organometallic chemistry, and enzymatic transformations.
Experience with analytical techniques such as NMR, mass spectrometry, IR spectroscopy, and X-ray crystallography.
Familiarity with computational chemistry tools like Gaussian, Schrodinger, or Materials Studio.
Research Experience: Proven track record of high-impact publications and conference presentations in synthetic chemistry or related fields.
Collaboration Skills: Strong ability to work in a multidisciplinary research environment, bridging experimental and computational domains.
Why Join OBS MIRD Entropy Labs?
At OBS MIRD Entropy Labs, you will:
Be part of a dynamic team that values curiosity, creativity, and innovation.
Work in a cutting-edge facility equipped with world-class resources, including Exa-scale computational platforms and advanced experimental tools.
Contribute to transformative research with potential applications across healthcare, energy, and technology sectors.
Receive competitive compensation, professional development opportunities, and the chance to collaborate with leading experts in the field.
If you are passionate about redefining the boundaries of synthetic chemistry and its applications, we invite you to join OBS MIRD Entropy Labs and become a driving force in shaping the future of science and technology.
Responsibilities
As a Synthetic Pathways Research Scientist at OBS MIRD Entropy Labs, your role involves advanced technical tasks spanning research, experimentation, modeling, and interdisciplinary collaboration. Below is a comprehensive list of responsibilities:
1. Research and Innovation
Design novel synthetic pathways for complex molecules, materials, or biochemical compounds.
Explore and implement green chemistry principles to develop sustainable and eco-friendly synthetic methodologies.
Investigate new catalytic systems, including homogeneous, heterogeneous, and enzymatic catalysts, to improve reaction efficiency.
Study reaction mechanisms using computational chemistry tools and validate them with experimental data.
Innovate in high-throughput synthesis techniques to enable rapid exploration of synthetic routes and conditions.
2. Computational Modeling and Prediction
Employ quantum mechanics-based tools (e.g., Gaussian, ORCA, Schrodinger) to model reaction pathways, thermodynamics, and transition states.
Utilize molecular dynamics and machine learning algorithms to predict optimal reaction conditions and potential side reactions.
Collaborate with computational scientists to integrate theoretical predictions into experimental workflows.
3. Experimental Development
Conduct hands-on laboratory experiments to synthesize target molecules or materials, optimize reaction conditions, and scale up production.
Develop innovative techniques for isolating and purifying complex reaction mixtures, including advanced chromatography and crystallization methods.
Use analytical tools such as NMR spectroscopy, mass spectrometry, X-ray diffraction, and FTIR to characterize synthesized compounds.
Implement automation and robotics in experimental setups to increase efficiency and reproducibility in synthetic workflows.
4. Scale-Up and Process Optimization
Translate laboratory-scale synthetic methods into scalable processes for industrial or pilot-scale production.
Design and test reactor systems for continuous-flow synthesis or batch processes to improve yield, efficiency, and safety.
Work with process engineers to address challenges in scale-up, including heat and mass transfer, solvent recycling, and waste minimization.
5. Interdisciplinary Collaboration
Partner with materials scientists to design advanced materials for energy storage, catalysis, or nanotechnology applications.
Collaborate with biochemists to engineer metabolic pathways for biosynthetic processes in pharmaceutical or biofuel production.
Engage with computational scientists to integrate predictive models into experimental design and process optimization.
6. Knowledge Dissemination and Reporting
Publish research findings in peer-reviewed journals and present at leading conferences in synthetic and computational chemistry.
Prepare comprehensive technical reports documenting experimental protocols, results, and interpretations.
Mentor students and junior researchers, fostering a collaborative and innovative research environment.
Qualifications
Educational Background
Academic Profile in Organic Chemistry, Inorganic Chemistry, Biochemistry, Materials Science, Chemical Engineering, or a closely related field.
Technical Expertise
Synthetic Chemistry:
Strong background in designing and optimizing synthetic routes for organic, inorganic, or hybrid compounds.
Experience with modern catalytic systems, including organometallic catalysis, enzymatic catalysis, and photocatalysis.
Analytical Techniques:
Proficiency in characterization methods, including:
NMR spectroscopy (1D and 2D techniques).
Mass spectrometry (GC-MS, LC-MS).
X-ray diffraction (single-crystal and powder).
FTIR and UV-Vis spectroscopy.
Hands-on experience with chromatography (HPLC, GC, column chromatography).
Computational Chemistry:
Familiarity with quantum chemistry tools (Gaussian, ORCA, VASP, etc.) for reaction mechanism studies.
Knowledge of molecular dynamics or machine learning techniques for predictive modeling.
Process Development:
Experience in scale-up of laboratory processes to industrial levels.
Knowledge of continuous-flow chemistry and reactor design.
Research Experience
Proven track record of publishing in high-impact journals or presenting at international conferences.
Demonstrated ability to design, execute, and interpret complex experiments independently.
Soft Skills
Strong analytical and problem-solving abilities.
Excellent written and verbal communication skills for technical and non-technical audiences.
Ability to work collaboratively in a multidisciplinary team setting.
Detailed Preferred Qualifications
While not mandatory, the following qualifications enhance a candidate’s application:
Advanced Technical Skills
Expertise in automation and robotics for synthetic chemistry applications.
Proficiency in advanced purification techniques, such as supercritical fluid chromatography or preparative HPLC.
Experience with machine learning models for synthetic route prediction and optimization.
Specialized Domain Knowledge
Knowledge of metabolic engineering and synthetic biology for biosynthetic applications.
Familiarity with sustainable chemistry practices, including renewable feedstocks and solvent recycling.
Expertise in polymer synthesis, nanomaterial fabrication, or supramolecular chemistry.
Leadership and Mentorship
Previous experience mentoring junior researchers or leading collaborative projects.
Proven ability to manage multiple research projects and prioritize effectively.
Funding and Outreach
Experience in securing research funding through grants or industry collaborations.
Demonstrated ability to effectively communicate research outcomes to stakeholders and the general public.
Special Domain Requirements
The position of Synthetic Pathways Research Scientist at OBS MIRD Entropy Labs involves expertise in cutting-edge domains of chemistry, materials science, and computational modeling. Below are the special domain requirements specific to this role, applying candidates must have proficiency in atleast 3 (Three) of the following specialization groups.
[Specialization Group A] Advanced Synthetic Chemistry
Proficiency in designing and executing novel synthetic strategies for complex molecules, functional materials, and bioactive compounds.
Expertise in multi-step synthesis, cascade reactions, and asymmetric catalysis.
Familiarity with emerging methodologies such as photoredox catalysis, electrochemical synthesis, and C–H activation.
[Specialization Group B] Sustainable and Green Chemistry
Strong understanding of green chemistry principles, including the use of renewable feedstocks, atom economy, and energy-efficient processes.
Experience in developing solvent-free reactions, recyclable catalysts, or water-based synthetic methodologies.
Knowledge of lifecycle assessment and environmental impact reduction in chemical processes.
[Specialization Group C] Computational Chemistry and AI Integration
Expertise in computational modeling of reaction mechanisms, transition states, and reaction energetics using tools such as Gaussian, VASP, or ORCA.
Familiarity with cheminformatics tools for virtual screening and property prediction.
Proficiency in leveraging AI and machine learning algorithms to predict synthetic routes, optimize conditions, and discover novel reaction pathways.
[Specialization Group D] Biochemical Pathways and Synthetic Biology
Knowledge of metabolic engineering and pathway optimization for biosynthetic production of complex molecules such as pharmaceuticals, biofuels, or natural products.
Experience in enzyme engineering, directed evolution, or biocatalyst design.
Familiarity with CRISPR/Cas9 or other gene-editing techniques to manipulate biosynthetic pathways.
[Specialization Group E] Materials Synthesis and Functionalization
Experience in designing and synthesizing advanced materials, including polymers, nanomaterials, and supramolecular structures.
Proficiency in developing materials for specific applications, such as energy storage (batteries, supercapacitors), catalysis, or drug delivery.
Understanding of the interplay between material structure, properties, and performance in applications.
[Specialization Group F] Process Development and Scale-Up
Expertise in continuous-flow chemistry and reactor design for process intensification.
Familiarity with industrial-scale synthetic processes, including cost analysis, safety considerations, and regulatory compliance.
Knowledge of advanced process analytical technologies (PAT) for real-time monitoring and control of chemical processes.
[Specialization Group G] Interdisciplinary Applications
Strong capability to apply synthetic pathways research to interdisciplinary domains, including:
Pharmaceutical Development: Synthesis of active pharmaceutical ingredients (APIs) and intermediates.
Energy Technologies: Development of synthetic methods for energy storage materials and fuels.
Nanotechnology: Fabrication of nanomaterials for sensors, electronics, and medical applications.
[Specialization Group H] Cutting-Edge Instrumentation and Techniques
Experience using high-resolution analytical tools, such as synchrotron X-ray diffraction or cryo-electron microscopy, to characterize materials.
Familiarity with advanced purification systems, such as preparative supercritical fluid chromatography (SFC).
Knowledge of robotics and automation in synthetic workflows to enhance reproducibility and scalability.
Why These Special Domain Requirements Are Important
These requirements ensure that the candidate is equipped to address the multifaceted challenges in synthetic pathways research at OBS MIRD Entropy Labs. With the lab's focus on leveraging Exa-scale quantum supercomputing and other advanced technologies, these specialized skills will contribute to groundbreaking innovations in chemistry, materials science, and biotechnology.
